Top Senior Machine Learning Jobs in Denver & Boulder, CO

Build scalable systems and machine learning models that transform satellite imagery into labeled geospatial data and production computer vision products. Responsibilities include developing data and annotation pipelines, tracking lineage and versioning, deploying inference services, evaluating models, supporting cloud infrastructure, and improving labeling workflows. The role requires strong Python, cloud, containerization, CI/CD, infrastructure-as-code, production support, and deep learning expertise, with preferred experience in GCP, Vertex AI, spatial databases, and satellite imagery.

Develop and maintain AI-driven autonomous planning, scheduling, and optimization systems for Earth observation satellite operations. Build reinforcement learning algorithms, simulation and evaluation environments, and multi-objective optimization pipelines for satellite constellation tasking. Collaborate with aerospace engineers, mission operators, software engineers, and product teams to translate mission requirements into deployable systems. The role requires strong Java and Spring Boot experience, software engineering fundamentals, and machine learning or optimization expertise.

Develop and operate production ML and AI systems powering patient experiences such as matching, ranking, recommendations, onboarding, and personalization. Build reusable ML infrastructure, pipelines, evaluation, observability, and model-serving capabilities. Provide technical leadership across the ML lifecycle, guide architecture, evaluate custom versus foundation-model approaches, and partner with ML and Patient Engineering teams to deliver reliable, scalable AI products.

Leads the AI Engineering team across applied AI features and foundational ML infrastructure. Responsibilities include managing Senior and Staff engineers, hiring and coaching, deploying LLM-powered capabilities, building MLOps and AI observability platforms, balancing product delivery with platform investment, and ensuring privacy, compliance, evaluation rigor, and clinical safety in production systems.

Develop and maintain production machine learning models, build scalable training and serving technologies, optimize real-time and batch ML pipelines, and monitor model performance and drift. The role involves deep neural networks, recommendation systems, automated retraining, ML research, engineering excellence, and communicating technical concepts to diverse audiences. Candidates need 6+ years of industry ML experience, strong coding skills, and experience deploying neural networks at scale.

Design, build, and support high-throughput, low-latency LLM inference and data pipelines; collaborate with data scientists to post-train and evaluate models; implement scalable, production-ready systems with strong testing, monitoring, and performance focus; mentor engineers and iterate on architecture, reliability, and user-facing AI applications.

Own and improve Quora’s second-phase ranking models for feed and digest experiences. Build end-to-end machine learning systems covering data pipelines, candidate extraction, feature engineering, model training, and production integration. Identify new product applications for machine learning, develop efficient algorithms with other ML engineers, and contribute methodologies for large-scale recommendation systems.

Build and operate production machine learning systems for Safety AI, including low-latency APIs, data pipelines, model serving, evaluation, monitoring, and rollout infrastructure. Process large-scale camera and telematics data, optimize cloud and edge-to-cloud execution, track model performance and drift, and partner with applied scientists, firmware engineers, platform teams, and product managers to deliver reliable safety features.

Leads Hightouch’s machine learning organization, including product development, technical roadmapping, recruiting, reliability, and people management. The role focuses on personalization, product recommendations, probabilistic identity resolution, LLM-powered content generation, and scalable machine learning infrastructure for model training and inference.

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Build and deploy production machine learning systems that optimize Samsara’s global hardware supply chain. Responsibilities include demand, inventory, lead-time, spend, and supplier-risk forecasting; anomaly detection; feature engineering and ETL; real-time inference; MLOps; data infrastructure improvements; governance; and model monitoring. The role defines the AI transformation roadmap, partners with executive and cross-functional stakeholders, mentors scientists, and drives adoption of AI-enabled operational workflows.

Design, build, evaluate, and productionize machine learning and LLM-based agentic systems for healthcare products. Own projects end-to-end, including problem framing, dataset development, modeling, evaluation, deployment, monitoring, and safety guardrails. Build ML infrastructure, data pipelines, inference systems, and evaluation frameworks. Collaborate with clinicians, product managers, and engineers, while setting technical direction and mentoring team members.

Develop autonomy evaluation metrics, statistical and machine-learning analyses, dashboards, and pipelines for simulation and on-road autonomous vehicle testing. Analyze perception, prediction, and planning performance; identify anomalous behavior and critical scenarios; apply VLMs and LLMs where appropriate; and support release gating and safety decisions. The role requires production Python, C++ debugging, technical leadership, cross-functional collaboration, and rigorous software engineering practices.

Leads and develops a team of autonomy engineers building multi-agent resource allocation, planning, coordination, and edge AI systems for spacecraft. Provides technical oversight on optimization, reinforcement learning, validation, architecture, and constrained real-time deployment. Owns team roadmaps, delivery, cross-functional dependencies, process improvement, and stakeholder communication while managing hiring, performance, career development, and team culture. The role bridges autonomy expertise with spacecraft constraints including compute, latency, power, and communication limitations.

Lead the development and production deployment of applied machine learning and LLM solutions across product, marketing, and operations. Own ranking, recommendation, filtering, personalization, experimentation, and model evaluation systems. Partner with business and technical teams to identify valuable use cases, establish modeling best practices, and ensure reliable production deployment. Manage and mentor applied ML practitioners while maintaining technical rigor, business alignment, and measurable customer and revenue impact.

Lead the design, development, deployment, and operation of production AI and ML systems. Build high-throughput Python services and Databricks pipelines, support traditional ML and LLM applications, establish testing and deployment standards, and develop monitoring for quality, reliability, latency, throughput, and cost. Partner with product, research, and responsible AI teams on governance and release criteria. Provide architectural leadership, conduct code reviews, mentor engineers, and resolve complex technical dependencies.

Leads Tala’s Machine Learning Engineering team in building and operating platforms for model development, real-time inference, streaming features, batch processing, deployment, monitoring, and production reliability. Manages and develops 4–6 engineers, owns delivery and prioritization, provides architectural leadership, improves engineering practices and SLOs, and partners with Data Science, Data Engineering, Product, Credit, and Business Development teams.

Leads and develops a perception and machine learning engineering team building computer vision, sensor fusion, tracking, detection, and scene-understanding capabilities for autonomous systems. Owns roadmap planning, technical decisions, delivery, model development and deployment workflows, field readiness, hiring, performance management, and cross-functional execution with autonomy, embedded, data, hardware, product, programs, and field operations teams.

Design, build, and maintain optimization technology, full-stack systems, and data-intensive scheduling infrastructure. Improve optimization algorithms using linear optimization, machine learning, and generative AI. Lead complex technical initiatives, establish testing and observability, support scalable operations, troubleshoot customer issues, participate in on-call rotations, and mentor engineers while partnering closely with product and engineering teams.

Design and deploy production recommendation and retrieval engines, build data orchestration pipelines for multiple modalities, implement agentic workflow frameworks, and prototype, optimize, and scale models with monitoring, governance, and low-latency SLAs.

Design, train, and deploy scalable ML models (generative, classification, regression). Define feature roadmaps, collaborate with engineering to implement code and APIs, adapt ML methods for distributed/GPU environments, and create evaluation/annotation programs for fine-tuning and performance measurement.

Build and scale production AI systems for Prophetic’s real estate intelligence platform. Responsibilities include developing agentic systems, data pipelines, inference workflows, evaluation benchmarks, geospatial processing, and machine learning applications across hundreds of millions of records. The role requires shipping reliable Python services, optimizing throughput and cost, integrating research into products, and collaborating with engineering and product teams.

Designs and delivers end-to-end AI/ML solutions on Google Cloud, including data ingestion, feature engineering, model training, deployment, and monitoring. The role leads client discovery, translates business needs into AI/ML strategies, develops roadmaps, provides technical leadership, and supports testing and user training. It requires hands-on Gemini and GCP expertise, customer-facing consulting experience, and collaboration across engineering and product teams.

Lead development and deployment of predictive and ML models for credit risk, collections, and operations. Mentor data scientists, promote MLOps and modern tools, present insights to stakeholders, and drive experimentation with techniques such as causal inference and GenAI.

Develop and deploy machine learning models and production software for multi-object tracking in autonomous trucks. Responsibilities include sensor fusion across camera, LiDAR, and radar; scalable PyTorch training workflows; tracking algorithm development; large-scale data analysis; C++ and Python engineering; safety and validation strategy; architecture decisions; and cross-functional collaboration. The role also provides technical leadership through design reviews, code reviews, mentoring, and engineering best practices.