Top Remote Machine Learning Jobs in Denver & Boulder, CO

Develop and operate production ML and AI systems powering patient experiences such as matching, ranking, recommendations, onboarding, and personalization. Build reusable ML infrastructure, pipelines, evaluation, observability, and model-serving capabilities. Provide technical leadership across the ML lifecycle, guide architecture, evaluate custom versus foundation-model approaches, and partner with ML and Patient Engineering teams to deliver reliable, scalable AI products.

Leads the AI Engineering team across applied AI features and foundational ML infrastructure. Responsibilities include managing Senior and Staff engineers, hiring and coaching, deploying LLM-powered capabilities, building MLOps and AI observability platforms, balancing product delivery with platform investment, and ensuring privacy, compliance, evaluation rigor, and clinical safety in production systems.

Develop and maintain production machine learning models, build scalable training and serving technologies, optimize real-time and batch ML pipelines, and monitor model performance and drift. The role involves deep neural networks, recommendation systems, automated retraining, ML research, engineering excellence, and communicating technical concepts to diverse audiences. Candidates need 6+ years of industry ML experience, strong coding skills, and experience deploying neural networks at scale.

Design, build, and support high-throughput, low-latency LLM inference and data pipelines; collaborate with data scientists to post-train and evaluate models; implement scalable, production-ready systems with strong testing, monitoring, and performance focus; mentor engineers and iterate on architecture, reliability, and user-facing AI applications.

Build and operate production machine learning systems for Safety AI, including low-latency APIs, data pipelines, model serving, evaluation, monitoring, and rollout infrastructure. Process large-scale camera and telematics data, optimize cloud and edge-to-cloud execution, track model performance and drift, and partner with applied scientists, firmware engineers, platform teams, and product managers to deliver reliable safety features.

Own the strategy, architecture, development, deployment, monitoring, and continuous improvement of production personalization and recommendation systems. Build custom embeddings, ranking models, and shared representations across feeds, search, and recommendations. Lead ambiguous problems from concept to measurable customer impact, establish AI evaluation standards, partner with product and data teams, make cross-team technical decisions, and coach senior engineers.

Design and deploy production machine learning models and conversational AI agents that transform advertiser briefs into optimized media plans. Build evaluation systems to improve model and agent quality, collaborate across science and engineering teams, investigate ambiguous problems, and iterate using performance data and seller feedback. Communicate effectively with technical and non-technical stakeholders while contributing broadly across machine learning domains.

Lead the design, development, testing, deployment, and productization of scalable AI/ML solutions. Build and optimize machine learning and deep learning models, transform prototypes into secure enterprise systems, and develop production-grade MLOps pipelines and CI/CD workflows. Guide AI/ML strategy, roadmaps, cloud deployments, and enterprise integration while mentoring engineering teams, advising customers, supporting workforce planning, and collaborating with technical and government stakeholders.

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Build and deploy production machine learning systems that optimize Samsara’s global hardware supply chain. Responsibilities include demand, inventory, lead-time, spend, and supplier-risk forecasting; anomaly detection; feature engineering and ETL; real-time inference; MLOps; data infrastructure improvements; governance; and model monitoring. The role defines the AI transformation roadmap, partners with executive and cross-functional stakeholders, mentors scientists, and drives adoption of AI-enabled operational workflows.

Design, build, evaluate, and productionize machine learning and LLM-based agentic systems for healthcare products. Own projects end-to-end, including problem framing, dataset development, modeling, evaluation, deployment, monitoring, and safety guardrails. Build ML infrastructure, data pipelines, inference systems, and evaluation frameworks. Collaborate with clinicians, product managers, and engineers, while setting technical direction and mentoring team members.

Develop autonomy evaluation metrics, statistical and machine-learning analyses, dashboards, and pipelines for simulation and on-road autonomous vehicle testing. Analyze perception, prediction, and planning performance; identify anomalous behavior and critical scenarios; apply VLMs and LLMs where appropriate; and support release gating and safety decisions. The role requires production Python, C++ debugging, technical leadership, cross-functional collaboration, and rigorous software engineering practices.

Build and operate Lakehouse data pipelines, product features, machine learning and generative AI components, testing, monitoring, instrumentation, and documentation. Collaborate with product managers, engineers, and business users to clarify requirements, deliver production solutions, investigate defects, and improve reliability and performance. Participate in code reviews, technical design discussions, and backlog-driven development while following engineering standards and contributing to scalable Data & AI products.

Build and deploy machine learning models on large healthcare datasets, extract actionable insights, develop scalable data processing systems, collaborate with cross-functional teams, and communicate findings to stakeholders to improve patient outcomes.

Designs, develops, trains, tests, and deploys secure AI and machine learning solutions for enterprise and government environments. Responsibilities include preparing datasets, identifying automation opportunities, evaluating model performance and security, documenting risks and controls, and collaborating with data scientists, software developers, cybersecurity engineers, architects, and domain experts. The role applies AI and ML to enterprise security engineering, testing, and mission workflows.

Design, develop, and implement AI/ML models; analyze large datasets; integrate AI solutions into existing systems; apply MavLink for autonomous systems; collaborate across teams and improve ML development processes.

Own the end-to-end architecture, development, deployment, evaluation, and operations of AI and machine learning systems. Build predictive ordering models, agentic workflow copilots, retrieval and evaluation infrastructure, safety guardrails, and responsible AI practices. Prioritize AI initiatives based on business outcomes, establish model governance and production standards, advise product and engineering leadership, and mentor experienced contributors.

Lead the development and production deployment of applied machine learning and LLM solutions across product, marketing, and operations. Own ranking, recommendation, filtering, personalization, experimentation, and model evaluation systems. Partner with business and technical teams to identify valuable use cases, establish modeling best practices, and ensure reliable production deployment. Manage and mentor applied ML practitioners while maintaining technical rigor, business alignment, and measurable customer and revenue impact.

Lead the design, development, deployment, and operation of production AI and ML systems. Build high-throughput Python services and Databricks pipelines, support traditional ML and LLM applications, establish testing and deployment standards, and develop monitoring for quality, reliability, latency, throughput, and cost. Partner with product, research, and responsible AI teams on governance and release criteria. Provide architectural leadership, conduct code reviews, mentor engineers, and resolve complex technical dependencies.

Build and operationalize machine learning models for large-scale advertising optimization. Responsibilities include designing high-volume services, developing data solutions, training and evaluating models, improving calibration and guardrails, creating offline and online evaluation workflows, and monitoring production systems. The role requires collaboration with product and engineering teams, ownership of reliability and performance, participation in on-call rotations, and deploying scalable, cost-effective ML solutions.

Leads the end-to-end design, deployment, and performance of real-time ML prediction and bid-optimization systems for programmatic advertising. Provides hands-on technical leadership to applied scientists and ML engineers, formulates optimization problems, manages production ML challenges such as latency, delayed feedback, drift, and retraining, and aligns technical roadmaps with business priorities.

Develops and productionizes deep learning and machine learning perception models for robotics and recycling sortation. Responsibilities include experimenting with neural network architectures, designing computer vision solutions, conducting statistical experiments, deploying successful models, collaborating with data, modeling, and cloud infrastructure teams, and improving ML infrastructure.

Leads Lyra Health’s AI/ML engineering roadmap, scales and mentors machine learning teams, and drives production-grade systems for clinical applications. Responsibilities include people leadership, quarterly planning, technical architecture, design reviews, model governance, ML SDLC oversight, and deployment of reliable microservices on Kubernetes. The role partners with product, data science, and clinical stakeholders while ensuring safety, operational excellence, cloud scalability, and compliance for sensitive healthcare data.

Leads Tala’s Machine Learning Engineering team in building and operating platforms for model development, real-time inference, streaming features, batch processing, deployment, monitoring, and production reliability. Manages and develops 4–6 engineers, owns delivery and prioritization, provides architectural leadership, improves engineering practices and SLOs, and partners with Data Science, Data Engineering, Product, Credit, and Business Development teams.

Leads and develops a perception and machine learning engineering team building computer vision, sensor fusion, tracking, detection, and scene-understanding capabilities for autonomous systems. Owns roadmap planning, technical decisions, delivery, model development and deployment workflows, field readiness, hiring, performance management, and cross-functional execution with autonomy, embedded, data, hardware, product, programs, and field operations teams.