Top Remote Staff Software Engineer Jobs in Denver & Boulder, CO

Build and lead development of the ESPM platform using Ruby on Rails. Define technical vision, design scalable data pipelines and architectures for petabyte-scale ingestion, implement features across the stack, collaborate with security researchers, mentor engineers, and ensure high-quality, tested deliveries.

The role involves leading application performance improvements across multiple platforms, focusing on measurable metrics and driving engineering standards and workflow optimization, using both hands-on coding and strategic influence.

Lead technical strategy and architecture for Coinbase's Blockchain Platform, overseeing nodes, indexers, wallets, and asset lifecycle. Drive cross-team platform rearchitectures, enforce security and reliability standards, champion AI-driven automation, use observability to improve reliability, and represent the platform to executives to secure alignment and resources for large-scale blockchain infrastructure initiatives.

The Security Software Engineer will design and implement security controls for MongoDB Atlas, collaborating across engineering teams and ensuring adherence to high security standards.

The Staff Software Engineer will design and build user-facing features for clinical AI applications, ensuring quality and security while collaborating cross-functionally.

Lead end-to-end engineering for an AI-driven biomanufacturing platform: design and deploy LLM-powered agents and RAG systems, build full-stack React/Node.js/MongoDB platform and document intelligence pipelines, evolve AWS infra for GxP/Part11/SOC2 compliance, implement CI/CD, observability, and work with customers to integrate with LIMS/ERP/QMS.

Lead design and delivery of customer-facing data product applications, building full-stack experiences (frontend, backend, APIs) using TypeScript, React, Node.js, and Python. Partner with Product and data teams to convert analytics and prototypes into production-grade workflows, establish software engineering best practices, mentor engineers, and prioritize customer value through testing, observability, and operational ownership.

Lead frontend architecture and product development for member-facing web and mobile apps. Build high-performance, accessible React/React Native UIs, own end-to-end features including APIs and backend services, mentor engineers, drive design system and frontend standards, and collaborate with Product, Design, Clinical, and Data teams to deliver scalable, user-centered health experiences.

Lead frontend architecture and technical direction for shared UI systems and design system. Build, maintain, and document reusable component libraries; collaborate with UX, product, and engineering. Champion accessibility, testing, performance, and design-to-code workflows. Mentor engineers, review contributions, and deliver major UI initiatives end-to-end while balancing technical debt and product needs.

Lead initiatives in designing and building large-scale distributed data systems and ML infrastructure, while collaborating across various engineering teams.

Lead architecture and productionization of NLP, voice, and ML systems; mentor engineers; integrate AI features with backend services on AWS; build evaluation, monitoring, and responsible-AI safeguards; drive AI strategy and technical vision.

The Staff Software Engineer will lead the design of the Integrations Platform's architecture, authoring framework, and integration strategies while coaching other engineers and ensuring high-quality integrations over multiple quarters.

The Staff Software Engineer will design and develop scalable cloud services, focusing on AI infrastructure, with hands-on system architecture, mentoring, and engineering culture shaping responsibilities.

Technical lead individual contributor who architects and delivers complex cross-team, customer-facing product initiatives. Partners with Product, Design, and Data to translate ambiguous problems into scalable solutions, raise engineering standards through code review and mentorship, address technical debt and performance, and influence roadmap and technical strategy.

Lead technical design and hands-on development of Pantheon’s data platform, extending ingestion, curation, retention services and ML/LLM infrastructure. Mentor engineers, drive architecture and engineering standards, operate in a DevOps model, partner cross-functionally, and participate in on-call support to ensure reliable, compliant data access and analytics.

Lead design, build, and operate enterprise-scale AI/MLOps platform infrastructure. Implement Kubernetes-native systems and infrastructure-as-code, ensure production reliability, security, and cost efficiency, create developer tooling and abstractions, collaborate with customers, mentor engineers, and drive platform architecture and priorities.

The Staff Software Engineer will architect and implement core services and systems, provide technical leadership, and mentor engineers while focusing on scalable, high-performance software development.

As a Staff Software Engineer, you’ll lead the design and reliability of Duetto's data lakehouse, evolving data systems using Python and AWS, ensuring data quality, and implementing AI-driven solutions.

Define architecture and technical roadmap for production AI/ML systems, productionize NLP and voice features in Python, mentor engineers, partner with product/medical teams to implement responsible safeguards, build evaluation and monitoring frameworks, own AWS Bedrock strategy, and drive long-term AI strategy and improvements across Fabric's products.

Lead technical vision and architecture for a scalable virtual care platform. Architect and develop Ruby on Rails backend, build React front end, guide technical decisions, collaborate cross-functionally, drive adoption of new technologies, and contribute to long-term product roadmap while mentoring engineers.

Lead the technical direction of a squad: own short- and long-term architecture, make major technical decisions, mentor engineers, run design/code reviews, improve quality, communicate with stakeholders, and contribute code.

Own architecture and technical strategy for authentication and authorization. Design and build Keycloak-based identity infrastructure and ReBAC authorization using Topaz/OPA. Develop IAM-adjacent services (directory, user management), establish cross-team authn/authz standards, drive technical roadmaps, scope projects, mitigate security and performance risks, perform architectural reviews, and mentor senior engineers.

Own and design high-impact components of Chainguard's container image platform. Build and improve image build systems, tooling, and services at scale. Drive technical direction, participate in roadmap planning, collaborate cross-functionally, and mentor engineers to raise engineering quality.

As a Staff Software Engineer on the Developer Platform team, you will enhance CI/CD pipelines, improve developer experience, and productionize AI tooling while mentoring teammates and collaborating with engineering leaders.

Lead design, development, and maintenance of scalable backend services for Payouts. Drive architecture, ensure performance and reliability, mentor engineers, enforce engineering best practices, and collaborate with product and support teams to deliver customer-facing REST APIs.