Top Remote Staff Software Engineer Jobs in Denver & Boulder, CO

Join the MongoDB Server Query Optimization team to build a distributed open-source query optimizer, focusing on enhancing query performance and robustness. Responsibilities include innovation in flexible schema databases, mentoring team members, and contributing to the technical roadmap based on extensive experience in the database domain.

The Staff Software Engineer will design and build user-facing features for clinical AI applications, ensuring quality and security while collaborating cross-functionally.

Drive the Continuous Integration team, ensuring build systems' reliability and scalability, and mentor CI engineers while improving developer productivity through automation and tooling.

As a Staff Software Engineer, you will lead the development of computer vision systems for sidewalk inspection, overseeing model lifecycle, system architecture, and mentoring while improving deployment practices.

The role involves leading application performance improvements across multiple platforms, focusing on measurable metrics and driving engineering standards and workflow optimization, using both hands-on coding and strategic influence.

Lead design, development, and operation of containerized microservices for offensive cybersecurity and user emulation. Drive architecture, mentor engineers, own end-to-end projects, define best practices, ensure reliability and security, collaborate cross-functionally, and implement monitoring, testing, and deployment pipelines for high-fidelity cyber range services.

Design, build, and maintain automation and testing infrastructure for the North platform: CI/CD pipelines, GitHub workflows, containerized test environments (Docker/Kubernetes), Helm and ArgoCD deployments, infrastructure-as-code, benchmarking, parallel test execution, and cross-team standards to improve test coverage, reliability, and deployment confidence.

As a Founding Staff Software Engineer, you will lead the design and development of robust backend systems and APIs, optimize large-scale data workflows, and mentor a growing engineering team.

The Senior Software Engineer will design and build scalable data solutions, manage backend systems, and enhance performance leveraging Golang and Python. Responsibilities include optimizing ETL processes and collaborating with teams to meet evolving customer needs.

As a Staff Software Engineer, you'll design and develop systems to integrate AI in healthcare payment processes, mentor engineers, and optimize workflows.

The Staff Software Engineer will design and build scalable backend systems, lead projects, and contribute to enterprise software solutions, focusing on application architecture, API development, and ML techniques.

The Staff Software Engineer will lead the software development lifecycle focusing on observability, design high-scale distributed systems, and mentor team members while ensuring technical excellence.

Design, build, and deploy enterprise-scale AI systems (agents, retrieval/RAG, generative AI) and reusable platforms. Own end-to-end solutions from discovery through production, testing, observability, and mentoring, driving architecture, standards, and cross-team adoption.

Lead technical direction for the ControlCheck team, design cross-domain systems (frontend, backend, infra), drive architectural decisions for Ruby on Rails and FastAPI services, de-couple and scale microservices, debug distributed systems, mentor senior engineers, coordinate cross-team dependencies, and influence engineering roadmaps without direct people management.

Build, operate, and scale core data services and APIs to process, store, and deliver large-scale patient health records with low latency and high availability. Provide technical leadership, contribute to architecture and design, collaborate with product and engineering teams, and coach engineers.

The Staff Engineer will lead the Systems team, design scalable cloud infrastructure, optimize data pipelines, and ensure platform reliability and security.

Lead a cross-functional engineering team with hands-on architecture and coding. Mentor engineers, drive technical execution, improve delivery practices, and collaborate with Product and QA to deliver reliable, modern cloud-based AI platform solutions.

Lead full‑stack development for the Care Journey product, owning design and delivery of GraphQL/Python APIs and React/React Native experiences. Write technical specs, drive large cross‑team projects, ensure HIPAA/GDPR compliance, mentor engineers, participate in on‑call, and deliver performant, scalable systems across web and mobile.

Lead end-to-end engineering of an AI-driven biomanufacturing platform: design and deploy LLM-powered agents and RAG systems, build full-stack React/Node/MongoDB pipelines, harden AWS infrastructure for regulated (GxP/Part 11) production, and deploy/integrate with customer LIMS/ERP/QMS.

Lead design and implementation of a production inference platform for LLMs. Define roadmap, integrate and optimize inference runtimes, manage GPU infrastructure, and build systems for deployment, autoscaling, observability, and operational excellence. Benchmark models/runtimes, partner with ML and product teams, make architectural tradeoffs, and mentor engineers to scale AI infrastructure.

The Staff Software Engineer will lead AI integration into software design, develop scalable systems, and mentor other engineers while improving best practices.

The role involves leading the architecture and implementation of hypervisor features, mentoring engineers, and driving technical vision for Lynx's Mosaic platform.

Lead delivery of high-complexity digital banking implementations: design and build Java Spring Boot microservices, REST APIs, cloud-native containerized deployments, data and DB migrations, event streaming, monitoring and performance optimization. Act as a customer-facing technical lead conducting code reviews, test strategies, and cross-functional coordination to resolve operational issues.

Lead the Payments Team by architecting and maintaining high-performance backend services, addressing complex engineering challenges, and mentoring engineering talent.

As a Senior Staff Engineer, you will lead technical vision and architectural direction for Payments Compliance, ensuring scalable and cohesive compliance systems while partnering with cross-functional teams to navigate regulatory requirements.