Top Remote Staff Software Engineer Jobs in Denver & Boulder, CO

The role involves architecting and improving data systems, defining governance standards, optimizing performance, and mentoring engineers in data engineering.

Serve as the technical IC leader for the Provider organization: set technical roadmap and engineering standards, design and review architectures, drive cross-team initiatives, mentor engineers, and deliver high-throughput, low-latency, cloud-based microservice systems for provider-focused products.

Design, build, and launch reliability engineering projects to scale production services. Improve scalability, observability, secrets/configuration management, canary-based deployments, and deployment safety. Partner with teams, support critical services, participate in on-call rotations, and promote reliability best practices.

Lead design and delivery of major product areas across web and mobile. Build and improve React/React Native apps, design scalable systems and data models, optimize performance, mentor engineers, set engineering standards, and collaborate with cross-functional stakeholders in a fully remote environment.

Build and operate Coinbase's LLM and agent platform: design the LLM gateway, agent runtime, knowledge bases, AI spend governance, observability/eval tooling, and ship production agents while partnering cross-functionally to ensure secure, cost-effective, and responsible generative AI at scale.

Lead design and implementation of developer tooling (SDKs, CLI, workflows), set API governance and technical standards, advocate developer experience across product teams, run community events and livestreams, and deliver high-impact cross-team SDK and platform initiatives to improve reliability, performance, and developer adoption.

The Staff Software Engineer will design and build user-facing features for clinical AI applications, ensuring quality and security while collaborating cross-functionally.

Lead the technical direction for the engineering team, architect systems, design APIs, and mentor engineers while improving backend infrastructure.

Lead technical direction and contribute to the frontend codebase, building user-facing tools and mentoring team engineers to enhance user experiences.

Design and build core LLM platform primitives, safety and observability infrastructure, provider abstraction and evaluation systems, prompt lifecycle and Agent-as-a-Service; collaborate with product teams, document reference implementations, and lead technical standards to enable other engineers to build production AI features.

The Staff Software Engineer will lead projects, mentor team members, write code using Python, Django, React, JavaScript, and TypeScript, and impact the healthcare system with software solutions.

Lead technical strategy and execution for enterprise software, design and build new systems, improve existing platforms, mentor engineers, collaborate with product and stakeholders, ensure quality/performance, share best practices, analyze costs, and support operational readiness including on-call production support.

As a Data Engineering Architect, lead the transformation of data engineering into a modern platform, oversee architecture and technical leadership, design scalable systems, ensure data quality and governance, and mentor teams for a data-driven culture.

Lead architecture and evolution of Juniper Square’s distributed services, cloud infrastructure, and developer platform. Design scalable, multi-tenant, event-driven systems; build paved-road developer tooling, CI/CD, and observability. Hands-on coding, prototyping, and performance troubleshooting. Enable production AI/LLM workloads, ensure security/compliance, support enterprise upmarket needs, and mentor engineering teams to raise operational excellence and reliability.

Build and own a framework-agnostic charting engine core and its React binding: rendering layers, real-time data plumbing, indicator math, drawing tools, performance (60fps) discipline, visual testing, architectural leadership, mentoring, and integrations across web and mobile.

Develop and maintain a digital ordering platform for medical equipment. Lead technical decisions, deliver quality code, and ensure system reliability while collaborating in an agile environment.

The Staff GenAI Backend Engineer leads engineering for intelligent routing systems, collaborates with teams to enhance customer support, and maintains architectural integrity in a high-availability environment.

As a Staff Software Engineer, you'll develop and maintain core platform infrastructure, design scalable systems, mentor junior engineers, and ensure reliability of product features.

As a Staff Software Engineer, you'll enhance the release and configuration systems across environments, optimize release pipelines, and provide tooling for reliable deployment, ensuring consistency and scalability while collaborating with various engineering teams.

The Staff Software Engineer will develop software solutions, mentor non-staff engineers, and enhance engineering processes while delivering high-quality products.

Lead the design and development of full-stack solutions for prescription decision-making, maintain backend systems, mentor engineers, and ensure system scalability.

As a Senior Staff Software Engineer, you will lead the design and development of AI-powered products, mentor team members, and architect backend systems using Python and modern frameworks while ensuring code quality and optimizing performance.

The Staff Software Engineer will lead feature delivery by building frontend and backend components, focusing on architecture, optimization, security, and performance in a fast-paced environment.

Lead the development team to enhance administrative tools, manage full stack web experiences, resolve performance issues, and mentor other developers.

Technical leader for the Planning and Recruiting team responsible for designing and scaling backend services for clinical trial matching, patient workflows, and provider integrations. Primarily backend-focused (Java/Kotlin) while contributing to frontend (React/TypeScript). Define architecture, APIs, observability, CI/CD, and production operations. Partner with product and design, lead cross-team initiatives, and mentor engineers to deliver reliable, scalable systems that improve clinical trial access.