Top Remote Staff Software Engineer Jobs in Denver & Boulder, CO

Build and operate Coinbase's LLM and agent platform: design the LLM gateway, agent runtime, knowledge bases, AI spend governance, observability/eval tooling, and ship production agents while partnering cross-functionally to ensure secure, cost-effective, and responsible generative AI at scale.

Lead design and implementation of developer tooling (SDKs, CLI, workflows), set API governance and technical standards, advocate developer experience across product teams, run community events and livestreams, and deliver high-impact cross-team SDK and platform initiatives to improve reliability, performance, and developer adoption.

Join the MongoDB Server Query Optimization team to build a distributed open-source query optimizer, focusing on enhancing query performance and robustness. Responsibilities include innovation in flexible schema databases, mentoring team members, and contributing to the technical roadmap based on extensive experience in the database domain.

Lead the Mapping Engineering team as a Staff Software Engineer, focusing on designing scalable distributed backend systems for autonomous vehicle mapping, collaborating with cross-functional teams, and mentoring engineers.

The Staff Software Engineer will design and build user-facing features for clinical AI applications, ensuring quality and security while collaborating cross-functionally.

Drive the Continuous Integration team, ensuring build systems' reliability and scalability, and mentor CI engineers while improving developer productivity through automation and tooling.

The role involves leading application performance improvements across multiple platforms, focusing on measurable metrics and driving engineering standards and workflow optimization, using both hands-on coding and strategic influence.

Lead architecture and implement scalable, secure core services and APIs. Drive design and code reviews, troubleshoot production issues, promote engineering best practices, and mentor junior engineers across multiple projects.

Build and maintain enterprise AI governance components (LLM gateway, Agent Firewall) across full stack (Go backend, React frontend). Ship features, harden security, integrate LLM provider APIs, collaborate with product, partners, and enterprise customers, and contribute to open-source tooling.

Founding platform engineering role to architect, build, and operate core platform systems (billing, integrations, Kubernetes/cloud infra, CI/CD, AI/LLM platform, observability). Own platform roadmap, mentor engineers, lead cross-team architecture, and diagnose/resolve production issues while establishing the Platform Engineering function.

Lead design and development of software that interfaces with quantum processors, supporting calibration, hardware interfaces, testing, monitoring, and operational infrastructure. Drive architecture, optimize performance, mentor engineers, run technical investigations, and participate in on-call rotations to ensure QPU solver availability on the Leap cloud platform.

Lead design, development, and operation of containerized microservices for offensive cybersecurity and user emulation. Drive architecture, mentor engineers, own end-to-end projects, define best practices, ensure reliability and security, collaborate cross-functionally, and implement monitoring, testing, and deployment pipelines for high-fidelity cyber range services.

Build and improve an embedded-Chromium architecture for Dia, design new APIs, collaborate across product and Chromium communities, create AI-driven tooling, support Chromium upgrades/releases, participate in on-call rotation, and speed debugging and development workflows.

Design, build, and maintain automation and testing infrastructure for the North platform: CI/CD pipelines, GitHub workflows, containerized test environments (Docker/Kubernetes), Helm and ArgoCD deployments, infrastructure-as-code, benchmarking, parallel test execution, and cross-team standards to improve test coverage, reliability, and deployment confidence.

As a Founding Staff Software Engineer, you will lead the design and development of robust backend systems and APIs, optimize large-scale data workflows, and mentor a growing engineering team.

The Senior Software Engineer will design and build scalable data solutions, manage backend systems, and enhance performance leveraging Golang and Python. Responsibilities include optimizing ETL processes and collaborating with teams to meet evolving customer needs.

As a Staff Software Engineer, you'll design and develop systems to integrate AI in healthcare payment processes, mentor engineers, and optimize workflows.

The Staff Software Engineer will design and build scalable backend systems, lead projects, and contribute to enterprise software solutions, focusing on application architecture, API development, and ML techniques.

The Staff Software Engineer will lead the software development lifecycle focusing on observability, design high-scale distributed systems, and mentor team members while ensuring technical excellence.

Design, build, and deploy enterprise-scale AI systems (agents, retrieval/RAG, generative AI) and reusable platforms. Own end-to-end solutions from discovery through production, testing, observability, and mentoring, driving architecture, standards, and cross-team adoption.

Lead technical direction for the ControlCheck team, design cross-domain systems (frontend, backend, infra), drive architectural decisions for Ruby on Rails and FastAPI services, de-couple and scale microservices, debug distributed systems, mentor senior engineers, coordinate cross-team dependencies, and influence engineering roadmaps without direct people management.

Build, operate, and scale core data services and APIs to process, store, and deliver large-scale patient health records with low latency and high availability. Provide technical leadership, contribute to architecture and design, collaborate with product and engineering teams, and coach engineers.

The Staff Engineer will lead the Systems team, design scalable cloud infrastructure, optimize data pipelines, and ensure platform reliability and security.

Lead a cross-functional engineering team with hands-on architecture and coding. Mentor engineers, drive technical execution, improve delivery practices, and collaborate with Product and QA to deliver reliable, modern cloud-based AI platform solutions.

Lead full‑stack development for the Care Journey product, owning design and delivery of GraphQL/Python APIs and React/React Native experiences. Write technical specs, drive large cross‑team projects, ensure HIPAA/GDPR compliance, mentor engineers, participate in on‑call, and deliver performant, scalable systems across web and mobile.