Top Remote Staff Software Engineer Jobs in Denver & Boulder, CO

Lead technical strategy and architecture for Coinbase's Blockchain Platform, overseeing nodes, indexers, wallets, and asset lifecycle. Drive cross-team platform rearchitectures, enforce security and reliability standards, champion AI-driven automation, use observability to improve reliability, and represent the platform to executives to secure alignment and resources for large-scale blockchain infrastructure initiatives.

The Staff Software Engineer will lead full-stack initiatives, improve system quality, drive technical direction, and mentor peers in a collaborative environment.

As a Staff Software Engineer, you'll lead AI-powered product delivery, shape platform architecture, and drive initiatives like advertising systems and AI-generated content.

The Security Software Engineer will design and implement security controls for MongoDB Atlas, collaborating across engineering teams and ensuring adherence to high security standards.

The Staff Software Engineer will design and build user-facing features for clinical AI applications, ensuring quality and security while collaborating cross-functionally.

Lead design, build, and operate enterprise-scale AI/MLOps platform infrastructure. Implement Kubernetes-native systems and infrastructure-as-code, ensure production reliability, security, and cost efficiency, create developer tooling and abstractions, collaborate with customers, mentor engineers, and drive platform architecture and priorities.

The Staff Software Engineer will architect and implement core services and systems, provide technical leadership, and mentor engineers while focusing on scalable, high-performance software development.

As a Staff Software Engineer, you’ll lead the design and reliability of Duetto's data lakehouse, evolving data systems using Python and AWS, ensuring data quality, and implementing AI-driven solutions.

Define architecture and technical roadmap for production AI/ML systems, productionize NLP and voice features in Python, mentor engineers, partner with product/medical teams to implement responsible safeguards, build evaluation and monitoring frameworks, own AWS Bedrock strategy, and drive long-term AI strategy and improvements across Fabric's products.

Lead technical vision and architecture for a scalable virtual care platform. Architect and develop Ruby on Rails backend, build React front end, guide technical decisions, collaborate cross-functionally, drive adoption of new technologies, and contribute to long-term product roadmap while mentoring engineers.

Lead the technical direction of a squad: own short- and long-term architecture, make major technical decisions, mentor engineers, run design/code reviews, improve quality, communicate with stakeholders, and contribute code.

Own architecture and technical strategy for authentication and authorization. Design and build Keycloak-based identity infrastructure and ReBAC authorization using Topaz/OPA. Develop IAM-adjacent services (directory, user management), establish cross-team authn/authz standards, drive technical roadmaps, scope projects, mitigate security and performance risks, perform architectural reviews, and mentor senior engineers.

Own and design high-impact components of Chainguard's container image platform. Build and improve image build systems, tooling, and services at scale. Drive technical direction, participate in roadmap planning, collaborate cross-functionally, and mentor engineers to raise engineering quality.

As a Staff Software Engineer on the Developer Platform team, you will enhance CI/CD pipelines, improve developer experience, and productionize AI tooling while mentoring teammates and collaborating with engineering leaders.

Lead design, development, and maintenance of scalable backend services for Payouts. Drive architecture, ensure performance and reliability, mentor engineers, enforce engineering best practices, and collaborate with product and support teams to deliver customer-facing REST APIs.

Lead the design and development of Pinecone's API and interfaces for AI agents, focusing on automation and observability while collaborating with cross-functional teams.

Develop, design, and maintain production software for autonomous mission management of a satellite constellation. Contribute to architecture, implement scalable algorithms in Python and Go, support production operations, on-call rotations, launches, and cross-team integration for automated constellation operations.

Lead design, development, and maintenance of SmithRx frontend features using JavaScript and React while ensuring high-quality code and scalability. Collaborate with product teams and mentor junior engineers.

Build and maintain backend systems, APIs, and data infrastructure powering member experiences and clinical workflows. Collaborate with frontend and product teams, ensure code quality, debug production issues, optimize performance and scalability, and propose new technologies.

Build and evolve Nexus interfaces for Temporal SDKs across multiple languages. Design and implement runtime APIs and behaviors, integrate SDKs tightly with language runtimes for durable, deterministic execution, collaborate with OSS community, write technical documentation, and own end-to-end features with high reliability.

Lead design, develop, and maintain scalable full-stack web applications. Mentor engineers, perform code reviews, troubleshoot production incidents, optimize performance, ensure API-first design, support cloud-native deployments (Kubernetes), and participate in on-call rotations.

Lead design, development, and maintenance of scalable, cloud-native web applications. Own end-to-end product features, mentor engineers, troubleshoot production incidents, improve performance, implement APIs, and support on-call rotations.

Lead product and technical discovery for a new initiative, build prototypes and end-to-end MVPs, define metrics and decision processes, rightsize architecture for iteration and integrations, and engage customers for feedback while coordinating external PM/design/business stakeholders.

Principal individual-contributor responsible for technical leadership and architecture of a scalable, secure API-driven digital pharmacy platform. Own system design, performance, PostgreSQL optimization, AWS infrastructure, cross-squad mentoring, compliance (HIPAA/SOC2), and prototyping to de-risk platform initiatives.

Design and build agentic LLM pipelines and full-stack AI features. Implement Python/FastAPI backends and TypeScript/React tooling, prompt-engineer models, develop eval datasets and observability, and partner with product teams to deploy reliable production LLM workflows.