Top Senior Systems Engineer Jobs in Denver & Boulder, CO

Leads mechanical systems engineering for satellite programs, including architecture, requirements, interface control, integration, verification, testing, mass properties, nonconformance resolution, and flight hardware support. Coordinates structural, thermal, mechanism, and propulsion subsystem integration while advising technical leadership on system-level risks. Drives mechanical design from concept through production and flight test, supports manufacturing and operations, and improves engineering workflows and digital engineering practices.

Provides senior systems engineering and IT consulting for multiple SMB clients. Designs, implements, migrates, and manages Microsoft-based infrastructure, cloud, virtualization, networks, servers, endpoints, and business continuity solutions. Serves as a trusted technical advisor, manages projects and client relationships, resolves complex issues, leads engineers, mentors new hires, and supports pre- and post-sales activities.

Leads complex spacecraft system integration and test activities across hardware and software subsystems. Manages requirements, architectures, concepts of operation, integration plans, verification, validation, test execution, anomaly resolution, milestone reviews, technical risks, and performance tracking. Collaborates with cross-functional engineering teams and subject matter experts while ensuring compliance with engineering processes and standards.

Lead complex presales engagements for Boomi’s API Management solutions across North America. Design API-first strategies, governance models, security policies, developer portals, and enterprise architectures. Advise executive stakeholders on digital ecosystems and business value, lead proofs of concept and RFI/RFP responses, and demonstrate integration between API Management and iPaaS capabilities. The role requires deep expertise in API lifecycle management, gateways, identity and security frameworks, cloud platforms, microservices, service mesh, and event-driven architectures.

Lead design, implementation, and maintenance of system architectures across applications, infrastructure, and cloud platforms for federal IT modernization. Provide technical leadership, ensure performance, reliability, and integration, produce documentation, and collaborate with DevOps, security, and stakeholders within Agile teams.

Architect, deploy, and operate highly available multi-cloud infrastructure across AWS and Azure. Manage Kubernetes, Linux systems, databases, caching platforms, CI/CD pipelines, infrastructure as code, observability, security, incident response, and performance optimization. The role also requires automation with Python and Bash, comprehensive documentation, client collaboration, and participation in a 24/7 on-call rotation.

Provides advanced remote IT support, systems administration, infrastructure troubleshooting, and technical escalation across client environments. Administers Microsoft 365, Windows Server, identity systems, Azure, networking, virtualization, endpoint management, and cybersecurity technologies. Mentors junior engineers, resolves complex tickets, maintains documentation and change controls, supports infrastructure initiatives, and evaluates emerging technologies. The role requires remote availability during West Coast Pacific Time business hours and effective communication in a managed services environment.

The Senior Systems Engineer I will develop and enhance mobile applications for cardiac health solutions, collaborating with engineers and cross-functional teams to ensure compliance with standards and successful project delivery.

Leads complex systems engineering activities including requirements engineering, architecture and design development, systems integration, verification and validation, MBSE, technical planning, risk management, and lifecycle management. Oversees major project deliverables, leads technical and decision analyses, mentors engineers, supports multidisciplinary development teams, and guides high-profile testing and supplier efforts. The role supports aerospace, ISR, aviation, and defense systems and requires a Secret security clearance.

Design, develop, integrate, test, and maintain secure ground systems supporting national security space missions. Define requirements and architectures, develop software, optimize system performance, document configurations, and ensure regulatory and security compliance. Collaborate with multidisciplinary teams, government customers, and contractors across the software lifecycle. Provide technical mentorship and operational support while applying systems engineering, cybersecurity, spacecraft communications, and safety analysis practices.

Own the architecture and evolution of Backblaze’s observability platform across multiple data centers. Lead metrics, logging, tracing, dashboards, infrastructure automation, Kubernetes deployments, Ceph monitoring, and network observability. Establish technical standards, capacity strategies, documentation, and operational practices while mentoring engineers and partnering across SRE, storage, network, security, and application teams. Evaluate AIOps and agentic AI solutions to improve incident detection, correlation, and response.

Designs, leads, and supports enterprise network security and infrastructure solutions. Responsibilities include network engineering, NAC, IAM, ZTNA, VPN, certificate and PKI management, secure connectivity, identity-driven access controls, segmentation, highly available distributed environments, platform upgrades, lifecycle management, and capacity planning. The role also evaluates technology solutions and leads cross-functional initiatives focused on performance, reliability, scalability, and capacity.

Develop and deliver high-fidelity threat modeling products for missile defense systems. Generate kinematic output data for simulated missile trajectories, support systems engineering and testing, troubleshoot modeling and simulation issues, and coordinate projects. The role requires onsite work at Schriever Space Force Base, collaboration with engineering teams, and occasional travel. Candidates must have active DoD Secret clearance and experience with missiles, six-degree-of-freedom trajectories, Linux and Windows platforms, and quality control.

Develop, integrate, verify, and operate satellite weather-sensing payloads. Translate mission objectives into requirements, architecture, verification plans, and interface definitions; coordinate payload integration with spacecraft teams; perform modeling, trade studies, orbital analysis, testing, and risk management; investigate anomalies and resolve technical issues across engineering and science teams.

Leads spacecraft systems engineering across requirements management, system architecture, concept of operations, integration, verification, and validation. Oversees technical milestone reviews, requirements traceability, risk mitigation, performance tracking, and configuration management while collaborating with cross-functional engineering teams. The role also mentors engineers and ensures compliant, cohesive system solutions throughout the development lifecycle.

Lead systems engineering for mission-critical space systems: define and trace requirements, perform trade studies, integration and verification planning, risk assessments, test support, and lead cross-functional teams to ensure mission readiness and safety.

Lead the definition, validation, and maintenance of system-level requirements for hypersonic systems, overseeing verification and qualification processes.

Senior systems engineer responsible for enterprise network and endpoint infrastructure in a complex healthcare environment. The role focuses on MECM/SCCM architecture, software distribution, operating system deployment, patching, virtualization, server administration, backup and recovery, disaster recovery, troubleshooting, capacity monitoring, technical recommendations, vendor escalation, and mentoring. The position is remote with on-call responsibilities and requires travel.

Designs, integrates, and maintains COMSEC solutions for national security space programs. Collaborates across cybersecurity, software, and hardware engineering teams; develops requirements, verification and validation plans, test plans, and traceability matrices; assesses communications security risks; manages COMSEC equipment and keying material; and ensures compliance with DoD, NSA, and cybersecurity regulations.

Own the architecture, design, qualification, and deployment of GPU-based compute payloads for Blue Origin’s orbital data center constellation. Responsibilities include GPU and component selection, compute module board and mechanical design, high-speed interconnect and fabric architecture, thermal integration, radiation and environmental qualification, EMI/EMC compliance, and collaboration with software and systems teams for AI/HPC workloads.

Develop and evaluate system safety, reliability, and risk processes for Blue Origin’s New Glenn orbital launch vehicle and facilities. Perform reliability modeling, safety analyses, hazard assessments, fault-tree and FMECA reviews, requirements traceability, and risk mitigation. Assess compliance with aerospace and safety standards, analyze flight data, report program metrics, maintain processes, and mentor engineers while integrating solutions across multidisciplinary systems engineering teams.

Lead design and implementation of data architecture and scalable storage solutions, drive AI/GenAI thought leadership, oversee data governance and security, translate business requirements into technical plans, implement FastAPI endpoints, enhance LLMs through prompt engineering, and manage cross-functional teams to deliver advanced data and AI solutions.

Supports USSF space test and training capabilities through feasibility studies, mission engineering, CONOPS, requirements management, systems integration, verification, validation, acquisition, fielding, and sustainment. Collaborates with government, engineering, acquisition, and program stakeholders while aligning technical efforts with PPBE activities. Requires extensive DoD systems engineering experience, space systems knowledge, Cameo and SysML expertise, an active Top Secret clearance with SCI eligibility, and up to 25% travel.

Lead architecture and implementation of Cloudflare Tunnel systems (client and edge services). Design, code, test, monitor, and scale distributed, secure microservices. Mentor peers, drive roadmap, debug production issues, and collaborate with security, SRE, network engineering, and product teams.

Leads the development, architecture, integration, verification, and deployment of spacecraft Ground Data Systems and space-to-ground communications. Responsibilities include defining requirements and interfaces, developing RF communications architectures, managing link budgets, testing ground modems and communications systems, coordinating with multidisciplinary teams and vendors, supporting software releases and operational training, and improving system operability across spacecraft and ground networks.