Senior Manager, Clinical Site Payments, Portfolio Management

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

General Description:
 

The Senior Manager, Clinical Site Payment Portfolio Management is responsible for global financial oversight, reconciliation, and portfolio-level governance of investigator grant payments across BeOne-sponsored clinical trials. This role partners closely with the Director of Clinical Site Payments, Head of CBO, Regional Clinical Site Payments teams, R&D Finance, Global R&D Sourcing (GRDS), payment vendors, and cross-functional stakeholders to ensure accurate financial reporting, accrual integrity, and compliance with SOX and internal control frameworks.

This position serves as a critical interface between Clinical Operations and Finance, responsible for end-to-end management of investigator grant financials, including monthly reconciliation, accrual accuracy, Budget vs. Actuals (BvA) tracking, and forward-looking financial forecasts.

The role also owns Clinical Site Payment portfolio metrics, reporting, and analytics dashboards, and ensures alignment of payments data with approved budgets, negotiated contracts, and the Clinical Payment taxonomy (CPT codes, CTP categories, subcategories) in accordance with the CPP Library framework.
 

1. Portfolio Financial Oversight & Reconciliation

• Lead monthly reconciliation of global investigator grant expenses, ensuring alignment across site payments, vendor disbursements, and financial ledgers
• Review and validate payment vendor drawdowns, ensuring appropriate funding levels and supporting documentation
• Partner with Regional Clinical Site Payments teams and vendors to investigate discrepancies and drive timely resolution
• Maintain a consolidated portfolio view of payments, accruals, commitments, and outstanding liabilities
   

2. Purchase Order (PO) & Financial Lifecycle Management

• Oversee creation, maintenance, and lifecycle management of Purchase Requisitions (PRs) and Purchase Orders (POs) for clinical site payments and vendors
• Ensure POs accurately reflect study budgets, amendments, and forecasted spend
• Monitor PO balances, utilization, and close-out activities to support financial accuracy and audit readiness
• Manage vendor invoice review, validation, and approvals in collaboration with GRDS and R&D Finance
   

3. Accruals, Close Process & BvA Analysis

• Own monthly PO accrual analysis and reporting in partnership with R&D Finance and GRDS
• Ensure accurate and timely investigator grant accruals in compliance with financial close timelines and SOX requirements
• Perform Budget vs. Actuals analysis at study and portfolio level, identifying key variances, trends, and financial risks
• Partner with R&D Finance and Treasury to support financial close activities and ensure completeness of recorded expenses
   

4. Clinical Site Financial Closeout & Unbilled Liability Forecasting

• Develop deep understanding of site-level financial closeout processes to ensure completeness of final investigator grant expenses
• Partner with GRDS and R&D Finance to identify and project outstanding expenses incurred but not yet invoiced by sites
• Ensure accrual coverage for unbilled costs through closeout periods and study transitions
• Support accurate financial representation of liabilities across the clinical portfolio
   

5. Financial Modeling, Forecasting & Scenario Analysis (Critical Capability)

• Develop and maintain financial models to support:
  • Accrual forecasting and cash flow projections
  • Scenario analysis (e.g., enrollment changes, study delays, vendor mix, FX rate impacts)
  • Internalization strategies for clinical payments
• Lead short-term and long-term forecasting for internalized countries in partnership with R&D Finance and Treasury
• Analyze impact of business and operational changes on financial performance and portfolio risk
   

6. Data Alignment, Reporting & Payment Analytics

• Own Clinical Site Payment KPIs, metrics framework, and reporting cadence
• Develop and maintain analytics dashboards (e.g., Power BI) to monitor:
  • Payment cycle times
  • Accrual vs. actual accuracy
  • Forecast deviations
  • Vendor performance and financial trends
• Partner with:
  • CBO Budget Planning & Strategy
  • Clinical Site Contracts
  • Clinical Site Data Hub

to ensure:

• Payments are aligned with approved budgets and negotiated contract terms
• Payment data is accurately mapped to CPT codes, categories, and subcategories
• Consistency with the CPP Library data structure across reporting systems

• Drive data integrity, standardization, and alignment across systems and stakeholders
   

7. Cross-Functional Partnership

• Act as primary liaison between Clinical Site Payments, R&D Finance, and Treasury for investigator grant financial management
• Collaborate with Global Clinical Operations and R&D Finance on budget assumptions and financial tracking methodologies
• Support strategic initiatives and project execution, including payment internalization and process optimization
   

8. Governance, Controls & External Audit Support

• Ensure adherence to SOX requirements and internal financial control frameworks
• Maintain audit-ready documentation for payments, accruals, reconciliations, and PO lifecycle management
• Lead quarterly external audit preparation by partnering with Regional Clinical Site Payments teams to compile and validate audit samples
• Coordinate with BeOne Controller and R&D Finance to support audit reviews and inquiries
• Identify control gaps and drive continuous improvements to strengthen financial governance
   

Supervisory Responsibilities:  

• None

Computer Skills:   

• Advanced knowledge Microsoft Office - Word, Excel, Power Point and MS Outlook; Smartsheet, SharePoint, MS Teams
   

Other Qualifications:

• Fluent in both written and verbal English.
• Strong proficiency in Excel, financial systems (SAP, Oracle, Ariba, Agiloft) and vendor clinical payment platforms, with the ability to manipulate and interpret key financial data effectively, and
• Exceptional accuracy and attention to detail.
• Proven ability to prioritize workload and manage multiple tight deadlines effectively in a fast-paced environment.
• Strong interpersonal skills, with demonstrated leadership, negotiation, analytical, and problem-solving abilities.
• Capable of multitasking and meeting compressed timelines.
• Ability to set priorities while managing multiple demands simultaneously.
• Critical thinker with a proactive approach to problem-solving.
• Self-starter with the flexibility to work independently while exercising sound judgment and initiative.
• Prior experience in clinical trial finance, clinical site budgeting, vendor sourcing, clinical operations, clinical payments, finance, and/or accounting.
• Proven ability to build and maintain financial models
• Cash flow forecasting and accrual projections
• Background in clinical and drug development within the biotech/pharmaceutical industry.
• Experience in clinical business operations, business process management, and project management.
• Strong understanding of SOX compliance and financial control frameworks
• Experience supporting financial close processes and audit readiness
• High attention to detail with strong focus on accuracy, documentation, and auditability

Travel: 

• As Needed
   

Education Required: 

• Bachelor’s degree from an Accredited College, and at least 7+ years’ experience in finance, biotech, pharmaceuticals, or a related field in the biotech/pharmaceutical industry

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process.  Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact [email protected].