The role involves designing PCR assays for NGS, analyzing sequencing data, and collaborating with various teams to enhance assay performance and oncology understanding.
Our bioinformatics team, working in biostatistics, genomics and bioinformatics in the next-generation sequencing (NGS) domain is expanding. We are searching for a bioinformatics data scientist to focus on design and improvement of PCR assays for high throughput NGS genomic sequencing. This exceptional opportunity offers the chance to work with a team focused on the forefront of genomic and cellular understanding of cancer.
Responsibilities:
- Work closely with software, experimental, regulatory, biological and clinical collaborators as a key member of the bioinformatics team in understanding assay performance
- Support the PCR primer/probe design. Identifies known and emerging nucleic acid biomarkers (SNV, InDel, DupDel, CNV, methylation, and fusions) via review of scientific papers and clinical trial summaries that drive treatment choices or are useful for monitor disease progression
- Analyze and interpret high-throughput internal DNA and RNA sequencing data from designed chemistry, with a specific focus on mutation identification and oncology characterization
- Improve biology/oncology understanding and assay performance based on the data.
Qualifications:
- MS with 3+ years of experience or PhD in genetics or related discipline
- Passionate about bioinformatics and data science
- Proven critical thinking capability with ability to follow through
- Proven understanding of both human genetics, oncology, and the genetic variation associated with various types of cancer
- Well versed with public sequence depositories of genome sequence and variation data, especially those focused on oncology and is able to query, retrieve, manipulate, and analyze data from these databases
- Experienced with the development of nucleic acid diagnostics based on the amplification of DNA and RNA via PCR
- Excellent communication (written and verbal) and data presentation skills.
Preferred:
- Deep knowledge and experience analyzing NGS data on human genome, either from industry or academia
- Proficiency with standard NGS tools like bwa, samtools, bedtools, etc.
- Experience working with somatic or low input DNA assays
- Experience and knowledge of commercially available of modern variant calling packages
- Proficient with excel or scripting language to analyze/understand NGS data
Pillar Biosciences aims to "Make precision medicine the first option for every patient" by developing and manufacturing targeted next-generation sequencing (NGS)-based assays and software for today’s high-throughput specialty NGS laboratories. We are seeking collaborative and independent problem solvers to support our mission.
Pillar Biosciences is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; religion; age; nationality; marital status; sexual orientation; disability or any other characteristic protected by law.
Similar Jobs
Biotech
The Bioinformatics Scientist analyzes lab-generated data, creates computational models, and develops tools for NGS data analysis, while collaborating with teams.
Top Skills:
BwaCloud ComputingGatkHpcPythonRRest ApiSamtoolsSQLUnix
Artificial Intelligence • Fintech • Hardware • Information Technology • Sales • Software • Transportation
The Customer Education Consultant develops and delivers tailored training plans for customers, leading training sessions and collaborating on learning materials to enhance customer product adoption and satisfaction.
Top Skills:
Articulate 360Captivate
Artificial Intelligence • Automotive • Greentech • Information Technology • Machine Learning • Software • Cybersecurity
The Client Integration Specialist II manages client integration processes, ensuring timely setup and support, while maintaining communication and attention to detail throughout the onboarding process.
Top Skills:
APIsFtpLinuxSalesforce CRMSQLWindowsXML
What you need to know about the Colorado Tech Scene
With a business-friendly climate and research universities like CU Boulder and Colorado State, Colorado has made a name for itself as a startup ecosystem. The state boasts a skilled workforce and high quality of life thanks to its affordable housing, vibrant cultural scene and unparalleled opportunities for outdoor recreation. Colorado is also home to the National Renewable Energy Laboratory, helping cement its status as a hub for renewable energy innovation.
Key Facts About Colorado Tech
- Number of Tech Workers: 260,000; 8.5% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Lockheed Martin, Century Link, Comcast, BAE Systems, Level 3
- Key Industries: Software, artificial intelligence, aerospace, e-commerce, fintech, healthtech
- Funding Landscape: $4.9 billion in VC funding in 2024 (Pitchbook)
- Notable Investors: Access Venture Partners, Ridgeline Ventures, Techstars, Blackhorn Ventures
- Research Centers and Universities: Colorado School of Mines, University of Colorado Boulder, University of Denver, Colorado State University, Mesa Laboratory, Space Science Institute, National Center for Atmospheric Research, National Renewable Energy Laboratory, Gottlieb Institute
