Top Remote Senior Level Machine Learning Engineer Jobs in CO

Lead the design and implementation of AI initiatives for edge devices. Develop and optimize machine learning solutions using large-scale sensor, video, text, diagnostic, transaction, and location data. Partner with engineering and business teams to prototype AI experiences, ship production systems, adopt research advances, and improve edge model performance. Mentor ML engineers and communicate technical concepts to varied audiences.

Build and scale production machine learning solutions for lottery fulfillment. Develop and optimize computer vision and multimodal models, fine-tune and evaluate models, create data pipelines and evaluation frameworks, and deploy models on cloud infrastructure. Integrate models into real-time systems involving image processing, barcode decoding, and OCR. Collaborate cross-functionally, improve engineering standards, mentor teammates, and support reliable nationwide expansion.

Lead complex modeling projects combining deep learning, LLMs, and traditional techniques. Prototype, deploy, and monitor production models, mentor data scientists, collaborate with engineering/product, and translate results into business impact for insurance customers.

Build scalable systems and machine learning models that transform satellite imagery into labeled geospatial data and production computer vision products. Responsibilities include developing data and annotation pipelines, tracking lineage and versioning, deploying inference services, evaluating models, supporting cloud infrastructure, and improving labeling workflows. The role requires strong Python, cloud, containerization, CI/CD, infrastructure-as-code, production support, and deep learning expertise, with preferred experience in GCP, Vertex AI, spatial databases, and satellite imagery.

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Own the reliability and quality of an AI copilot for a trading platform. Build evaluation frameworks, benchmarks, quality gates, monitoring, incident response, and model improvement workflows. Partner with engineering and product to create safe, auditable tool interactions and improve assistant behavior. Develop domain expertise in trading, risk, margin, execution, and portfolio reasoning while operating across model, backend, and frontend systems.

Develop and operate production ML and AI systems powering patient experiences such as matching, ranking, recommendations, onboarding, and personalization. Build reusable ML infrastructure, pipelines, evaluation, observability, and model-serving capabilities. Provide technical leadership across the ML lifecycle, guide architecture, evaluate custom versus foundation-model approaches, and partner with ML and Patient Engineering teams to deliver reliable, scalable AI products.

Leads and mentors Applied Scientists developing, evaluating, and deploying machine learning and language-model solutions for healthcare workflows. Translates clinical and business problems into scalable AI systems, applies rigorous statistical methods and experimentation, partners with engineering and cross-functional stakeholders, and ensures models are reliable, reproducible, and safe. The role also contributes hands-on technical work, recruiting, onboarding, and team development.

Develop autonomy evaluation metrics, statistical and machine-learning analyses, dashboards, and pipelines for simulation and on-road autonomous vehicle testing. Analyze perception, prediction, and planning performance; identify anomalous behavior and critical scenarios; apply VLMs and LLMs where appropriate; and support release gating and safety decisions. The role requires production Python, C++ debugging, technical leadership, cross-functional collaboration, and rigorous software engineering practices.

Design and deploy machine learning models for financial document processing, optimize large language models, collaborate with cross-functional teams, and guide junior peers in a fast-paced environment.