Top Remote Senior Level Machine Learning Engineer Jobs in CO

Manage a team of ML engineers to build and optimize Affirm's economic decisioning engine using advanced ML techniques. Collaborate across teams, provide technical leadership, and mentor engineers while driving a cohesive long-term ML strategy.

Take Deepgram's speech models and optimize, compile, and run them on resource-constrained embedded and edge hardware. Work across model compression, runtime performance (C/C++/Rust), RTOS/bare-metal and embedded Linux environments, vendor NPUs/DSPs and inference runtimes, benchmarking, deployment pipelines, OTA updates, and partner with silicon vendors to enable real-time, low-power on-device voice experiences.

Design, build, and deploy production-grade ML systems for ICS/xOT cybersecurity, including threat detection, anomaly detection, NLP/LLM applications, and scalable data pipelines with observability and MLOps practices for cloud and on-prem environments.

The Machine Learning Engineer develops production ML algorithms and recommendation systems, collaborates with teams, and optimizes user experiences.

The Sr. Machine Learning Engineer will develop and deploy ML solutions for healthcare, manage data pipelines, and work with large datasets to enhance healthcare delivery.

As a Staff Applied ML Scientist, you will develop and maintain fraud detection models, conduct research on fraud types, and collaborate across teams to drive product development and real-time decision-making.

Lead the development of machine learning systems for Cedar Pay's Personalization Engine, manage ML engineers, and ensure ML model effectiveness.

As a Staff Machine Learning Engineer, you will design AI products on Edge devices, optimize ML model performance, and work with large-scale datasets, collaborating across teams to deliver impactful solutions.

The Staff Machine Learning Engineer will lead ML initiatives, develop ML systems, collaborate with cross-functional teams, and mentor junior engineers to optimize healthcare intake workflows using advanced machine learning techniques.

Lead design and delivery of low-latency market-making and automated trading strategies. Translate quantitative research into production systems, build backtesting and real-time decision engines, ensure scalability and observability, manage risk-aware optimization, and influence cross-functional teams on strategy and technical direction.