Staff/Sr. Staff/Principal I Engineer, Bioinformatics Software

Staff/Sr. Staff/Principal I Engineer, Bioinformatics Software

We are seeking an experienced Bioinformatics Software Engineer specializing in C++ to join our Instrument Analysis team at PacBio (NASDAQ: PACB). In this role, you will develop high-performance on-instrument software tools and algorithms that further our mission to advance scientific understanding through cutting-edge technologies. This position demands deep technical expertise in modern C++ development, along with specialized knowledge of bioinformatics algorithms and statistical modeling. 

Responsibilities: 

• Design and implement efficient bioinformatics algorithms for sequence analysis in modern C++, meeting performance-critical requirements. 
• Profile and optimize code to enhance memory efficiency and computational speed. 
• Develop clean, well-documented APIs and libraries suitable for integration into broader software ecosystems. 
• Collaborate with team members, sharing insights and best practices, and fostering a culture of continuous improvement. 
• Maintain comprehensive and clear documentation covering software design, implementation, and optimization strategies. 

Required Qualifications: 

• Master's or Ph.D. in Bioinformatics, Computational Biology, Computer Science, or a related field. 
• 5+ years of professional C++ development experience using modern standards. 
• Expert-level understanding of core bioinformatics concepts, particularly in sequence analysis. 
• Proven experience developing complex algorithms with careful consideration of time and space complexity. 
• Proficiency with version control (Git), automated testing, continuous integration, and code review processes. 
• Experience with memory management, multi-threading, and system-level optimization. 
• Familiarity with common bioinformatics file formats (FASTA, FASTQ, SAM/BAM/CRAM, VCF). 
• Demonstrated ability to debug complex software systems and identify performance bottlenecks. 
• Excellent interpersonal, written, and verbal communication skills. 

Preferred Experience: 

• Knowledge of statistical methods and machine learning techniques in bioinformatics. 
• Familiarity with scientific visualization libraries and tools. 
• Contributions to open-source bioinformatics projects or tools. 

This role is not eligible for visa sponsorship. 

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home).  Depending on the role, some employees may be required to be 100% onsite. 

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties. 

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. 

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. 

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All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or [email protected] for assistance.

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