Eli Lilly and Company
Senior Advisor – Discovery ADMET (ADME, Toxicology) Project Leader
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Job Title: Senior Advisor – Discovery ADMET (ADME, Toxicology) Project Leader
Organization Overview
Lilly is a global healthcare leader headquartered in Indianapolis, Indiana. Our 50,000 employees around the world work to discover and bring life-changing medicines to those who need them. At Lilly, the Discovery Investigative ADME, Toxicology and BioAnalytical Research team focuses on pre-clinical discovery using innovative science and technology approaches to treat diseases with poor treatment options.
Position Summary
We are seeking an experienced, accomplished drug hunter as a Discovery ADME Project Leader. The ideal candidate will provide deep mechanistic understanding of drug disposition, PK, and translational science, plus the ability to integrate biology, chemistry, and modeling. Experience with Small Molecule Discovery and in project teams with Beyond-Rule-of-Five and pan-modality chemo-types is advantageous. The successful candidate will bring outstanding scientific depth and acumen as an integral member of the project team to build ambitious Target Product Profiles, help establish design strategy and expectations, partner globally and cross-functionally and ensure teams are advancing The Right Molecule to The Right Study at The Right Time (our three R’s).
Geography for this position is open to Indianapolis IN, Louisville CO or Boston MA.
What You Will Do
Keep Safety as a priority.
Develop and implement integrated preclinical ADMET strategies aligned with discovery stage, target product profile (TPP), design hypotheses being tested, and regulatory expectations.
As the ADMET Project Leader, bring integrated Toxicology subject matter expertise, driving integrated ADMET strategy by aligning pharmacokinetics, metabolism, and mechanistic disposition data with early safety signals; interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to proactively de-risk programs and enable data-driven candidate selection decisions.
Integrate ADME, pharmacology, and toxicology to enable translational simulations and modeling to support dose selection, design of PK/PD, efficacy and safety studies.
Define stage-, modality-, and issue-appropriate screening, decision funnels (in silico, in vitro, in vivo to translational modeling).
Guide compound design and optimization through data-driven design principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
Serve as the ADMET strategy and science single-point-of-accountability on cross-functional program teams, translating ADMET findings into actional design and test hypotheses.
Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery Functions to drive high quality candidate selections. Contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
Represent ADMET in portfolio governance discussions and leadership reviews.
Implement standards, assay innovation, and automation where appropriate. Drive innovation in data reporting, knowledge management, and decision frameworks. Seek and leverage AI and agentic tools where possible to pipeline data, interpret data and share results.
Maintain inspection-ready documentation and alignment with regulatory expectations.
Mentor, guide and grow junior scientists and contribute to functional capability building.
Minimum Qualifications
PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or scientific field.
3+ years of post-graduation industry experience in a drug discovery environment, driving discovery teams and experience in the life cycle/flywheel (Design, Make, Test, Analyze) of a discovery project.
3+ years experience in ADME/PKPD
Preferred Qualifications:
- Expertise and a working knowledge of medicinal chemistry, and Toxicology principles.
Exceptional written and verbal communication skills; ability to successfully navigate ambiguity and/or global cross-functional collaborations.
Demonstrated ability to translate complex technical concepts into strategic value for senior leadership and cross-functional partners.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$151,500 - $281,600Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
Similar Jobs
What you need to know about the Colorado Tech Scene
Key Facts About Colorado Tech
- Number of Tech Workers: 260,000; 8.5% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Lockheed Martin, Century Link, Comcast, BAE Systems, Level 3
- Key Industries: Software, artificial intelligence, aerospace, e-commerce, fintech, healthtech
- Funding Landscape: $4.9 billion in VC funding in 2024 (Pitchbook)
- Notable Investors: Access Venture Partners, Ridgeline Ventures, Techstars, Blackhorn Ventures
- Research Centers and Universities: Colorado School of Mines, University of Colorado Boulder, University of Denver, Colorado State University, Mesa Laboratory, Space Science Institute, National Center for Atmospheric Research, National Renewable Energy Laboratory, Gottlieb Institute
