Lead and grow the mobile and AI platform engineering team to deliver reliable, real-time DNA-based health insights. Own roadmap, delivery predictability, React Native releases, performance, production reliability, AI model orchestration, multi-agent systems, incident response, API contracts, and cross-functional partnerships to ensure scalable, trustworthy AI experiences.
Sequencing is building the interface between humanity and its DNA.
Using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications, we help people better understand themselves, their health, and their future through their DNA.
The human genome is one of the most valuable and underutilized resources in the world. Our mission is to transform the human genome into a lifelong source of personalized guidance and build the trusted home for every genome on Earth.
As the world’s largest direct-to-consumer whole genome sequencing platform, Sequencing is helping define the future of AI-powered personalized health.
We’re a profitable, venture-backed, fully remote company building category-defining products that help people better understand themselves through their DNA.
The Engineering Manager, Native App & AI Platform, leads the team responsible for Sequencing.com’s AI health experience across the React Native mobile app and the underlying AI platform. This role reports into senior engineering leadership and partners closely with the AI Technical Lead, who owns architecture and technical direction, while owning day to day execution, delivery discipline, production reliability, and team health.
This is a people leadership role as much as a technical delivery role. The focus is on leading mobile frontend execution, strengthening the underlying AI platform, and building the operating discipline, team structure, and production reliability needed to deliver trustworthy, real time health insights from DNA at scale.
- Own roadmap sequencing, delivery predictability, and capacity planning across the Native App and AI Platform.
- Drive predictable React Native releases across iOS and Android, with strong focus on frontend quality, product execution, and customer experience.
- Lead and develop a distributed team of engineers through coaching, regular 1:1s, hiring, performance management, and clear day to day accountability.
- Improve app performance, stability, and deployment reliability so customers can trust their health insights any time they open the app.
- Keep backend contracts and APIs clean and stable so mobile and platform teams can move quickly without creating friction or rework.
- Drive production grade implementation of multi agent architecture, planner agents, retrieval systems, model orchestration, and latency optimization.
- Build evaluation and regression checks into release workflows so health insights stay stable as the system evolves.
- Set and enforce clear targets for performance, reliability, and latency so the AI app responds in real time.
- Maintain clean architectural boundaries between AI platform and core systems so the platform remains understandable and maintainable over time.
- Build team resilience and reduce key person dependencies so the platform can scale sustainably.
- Lead AI related incident response, postmortems, and long term fixes so sensitive health data and insights stay dependable.
- Partner with Product, Bioinformatics, and Data to turn AI complexity into clear plans, accuracy guardrails, and measurable AI performance.
- Communicate clearly with leadership when focus is high on AI quality and reliability.
Dominant and Recessive Traits
- 7+ years of engineering management experience working with high complexity, high visibility systems.
- Strong people management experience, including coaching, 1:1s, hiring, and performance management.
- Experience leading native mobile engineering teams, ideally with React Native across iOS and Android.
- Strong frontend and product delivery instincts, with ability to lead customer facing mobile experiences, not just backend execution.
- Experience leading AI infrastructure, AI platforms, or distributed backend teams handling sensitive or mission critical data.
- Familiarity with multi agent systems, planner agents, retrieval architecture, model orchestration, and ML backed production systems.
- Strong backend foundation in TypeScript or a similar production environment.
- Proven record of improving execution predictability and delivery discipline in engineering teams.
- Comfortable enforcing architectural guardrails and clean boundaries between systems and teams.
- Power user of AI and LLM tools for planning, communication, and process design. This is not optional.
- Strong command of project management and documentation tooling, including Jira, Confluence, and similar systems.
- Experience managing and supporting distributed teams in fully remote environments.
- Clear communicator who can turn deep technical details into simple operational plans for non technical partners.
- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential)
- Redefine how people understand themselves through their DNA
- Build category-defining products alongside scientists, engineers, and innovators
- Contribute to technology that will improve and extend millions of lives
- Shape one of the most important emerging categories in AI and healthcare
Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting [email protected].
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