The Director of Data Engineering & Analytics will lead the design and implementation of Apogee's Data Lakehouse, focusing on various operational use cases and ensuring compliance in a regulated environment.
About Apogee Therapeutics
Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally.
Apogee Therapeutics, Inc. is a biotechnology company seeking to develop differentiated biologics for the treatment of atopic dermatitis, chronic obstructive pulmonary disease and other inflammatory and immunology indications with high unmet need. Our antibody programs are designed to potentially overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. We seek to reshape the current standard of care for inflammatory and immune diseases because we believe people living with these diseases deserve the best possible treatment, and we refuse to stop at “good enough.”
We are a fast-paced company committed to building an exceptional company culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless.
If this sounds like you, keep reading!
Role Summary
We are seeking a Director, Data Engineering & Analytics to be a hands-on, individual contributor leading the design, implementation, and evolution of Apogee’s new enterprise Data Lakehouse and analytics ecosystem. This role will be the primary internal owner of our Data Lakehouse, delivered in partnership with a Systems Integrator, and will initially focus on Clinical Development and Clinical Operations use cases (e.g., study oversight, medical monitoring, operational performance). Over time, the platform will expand to support Technical Operations, Commercial, Medical Affairs, and Finance.
Key Responsibilities
Data Lakehouse Strategy, Design & Implementation
- Serve as the primary owner of Apogee’s Data Lakehouse architecture, roadmap, and implementation, in close partnership with a Systems Integrator
- Define the data platform to support Clinical Development and Clinical Operations, with a clear path to extend to Technical Operations, Commercial, Medical Affairs, and Finance
- Design and oversee data ingestion, transformation, and storage for structured and semi-structured data from key Apogee sources, including external CRO systems (e.g., EDC, CTMS, safety, statistical outputs)
- Establish and maintain subject area data models and semantic layers tailored to clinical and operational use cases
- Ensure the platform is designed and operated in alignment with Apogee’s GxP, 21 CFR Part 11, SOX Controls, and other regulatory/compliance expectations, where applicable
Data Engineering, Modeling & Governance
- Design, build, and maintain end-to-end data pipelines (ingestion, transformation, curation) into the Data Lakehouse using modern data engineering practices
- Develop and maintain data models that serve Clinical Development, Clinical Operations, and later Tech Ops and Commercial / Med Affairs / Finance
- Implement data quality, lineage, and metadata practices, working with business data owners to define critical data elements and trusted metrics
- Contribute to defining data governance at Apogee, including data ownership, stewardship, and standardized KPI and metric definitions across functions
Analytics, BI & Visualization
- Design and build dashboards / analytic views that support key functional area use cases
- Define reusable data marts and semantic models that enable self-service analytics for Clinical and, over time, other functions
Cross-Functional Leadership & Change Management
- Act as a trusted partner to Clinical Development, Clinical Operations, Biometrics, Medical Monitoring, and other functions, translating their questions into implementable data and analytics solutions
- Work closely within IT (Infrastructure and Security), QA, and business stakeholders to support any required validation, testing, and controlled releases of data and analytics capabilities
- Communicate roadmaps, status, risks, and dependencies clearly and regularly to technical and non-technical stakeholders, including senior leadership
- Drive adoption and literacy around the Data Lakehouse and BI tools by developing documentation, providing training/enablement for key users, and promoting best practices
- Help define the future operating model for data and analytics at Apogee, including when and how to scale into a broader team
Ideal Candidate
- 10+ years of experience in data engineering, data platform, or analytics roles, with meaningful experience owning or leading a modern cloud data platform (Data Lakehouse or cloud data warehouse)
- Bachelor’s degree (or equivalent professional experience) in Life Sciences, Information Systems, Engineering, or related field
- Proven track record as a hands-on senior level individual contributor, comfortable both setting strategy and implementing technical solutions
- Experience with cloud-based data platforms (e.g., Databricks, Snowflake, BigQuery, or similar) and modern data stack components
- Strong expertise in data modeling and ETL/ELT for analytics and reporting, including building reusable, production-grade data assets
- Experience working closely with integration teams (ideally with MuleSoft or similar) and understanding how operational integrations and data pipelines intersect
- Prior experience in biotech / pharma / life sciences is strongly preferred, especially supporting Clinical Development, Clinical Operations, Biometrics, or Medical Monitoring
- Familiarity with data from CROs and clinical systems (e.g., EDC, CTMS, safety, lab, statistical outputs) and integrating these into a centralized data environment
- Experience working in regulated environments (e.g., GxP, 21 CFR Part 11, HIPAA) and supporting audit/inspection readiness is highly desirable
- Exposure to Apogee-relevant systems is a plus (e.g., Veeva Vault applications, Egnyte GxP repositories, SAS server, NetSuite)
- Strong proficiency in SQL and at least one data engineering language (e.g., Python or Scala)
- Hands-on experience with data pipeline and orchestration tools (e.g., Airflow, Azure Data Factory, dbt, or similar) and CI/CD concepts for data workloads
- Solid understanding of data architecture patterns (data lakes, lakehouses, warehouses, dimensional modeling, semantic layers)
- Experience integrating data from file repositories (SharePoint, Egnyte) and external partners (CROs, cloud vendors, etc.)
- Strong understanding of data security, privacy, and access control in an enterprise setting, and how these intersect with GxP and other compliance requirements
- Strategic yet pragmatic; able to start from a greenfield environment and design a phased, realistic roadmap
- Excellent communication and storytelling skills, capable of framing data and platform decisions in business terms for clinical and executive stakeholders
- Demonstrated ability to lead through influence, collaborating effectively with integration, infrastructure, security, QA, and business teams without direct reporting lines
- High ownership and bias for action, comfortable operating in a fast-paced, high-growth clinical-stage biotech environment
- Interest in eventually building and leading a small data team, while being fully comfortable as a hands-on individual contributor in the near term
- Ability and willingness to travel up to 20%, including mandatory in-person attendance at Apogee All Hands meetings typically held twice per year
The anticipated salary range for candidates for this role will be $220,000 - $235,000. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.
What We Offer
- A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless
- Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly
- Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
- We provide competitive time off, including three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave
- Commitment to growing you professionally and providing access to resources to further your development
- Apogee offers regular all team, in-person meetings to build relationships and problem solve
E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster.
Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.
To review our privacy policy, click here
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Top Skills
Airflow
Azure Data Factory
BigQuery
Data Lakehouse
Databricks
Dbt
Python
Scala
Snowflake
SQL
Similar Jobs
.png)
Greentech • Energy
Lead the data engineering and analytics team, overseeing data processing for utility bills, building data strategies, and ensuring data quality while promoting evidence-based decision-making across the organization.
Top Skills:
AirbyteAirflowAWSAzureDagsterDbtFivetranGCPHexPythonSnowflakeSQL
Greentech
This role involves building and leading a data team to analyze millions of utility bills, ensuring data quality and scalability while crafting a long-term data strategy.
Top Skills:
AirbyteAirflowAWSAzureDagsterDbtFivetranGCPHexPythonSnowflakeSQL
Edtech
The Director of Data & Analytics will lead analytical engineering strategy, mentor a data team, and create actionable data models for business decisions.
Top Skills:
DatabricksDbt CloudPower BIPythonSQL
What you need to know about the Colorado Tech Scene
With a business-friendly climate and research universities like CU Boulder and Colorado State, Colorado has made a name for itself as a startup ecosystem. The state boasts a skilled workforce and high quality of life thanks to its affordable housing, vibrant cultural scene and unparalleled opportunities for outdoor recreation. Colorado is also home to the National Renewable Energy Laboratory, helping cement its status as a hub for renewable energy innovation.
Key Facts About Colorado Tech
- Number of Tech Workers: 260,000; 8.5% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Lockheed Martin, Century Link, Comcast, BAE Systems, Level 3
- Key Industries: Software, artificial intelligence, aerospace, e-commerce, fintech, healthtech
- Funding Landscape: $4.9 billion in VC funding in 2024 (Pitchbook)
- Notable Investors: Access Venture Partners, Ridgeline Ventures, Techstars, Blackhorn Ventures
- Research Centers and Universities: Colorado School of Mines, University of Colorado Boulder, University of Denver, Colorado State University, Mesa Laboratory, Space Science Institute, National Center for Atmospheric Research, National Renewable Energy Laboratory, Gottlieb Institute
