Colorado is a growing hub for healthcare innovation, with companies tackling some of the industry’s biggest challenges with technology. From virtual care platforms and at-home medical services to chronic disease management, pharmacy delivery and healthcare data infrastructure, the state’s healthtech ecosystem is helping reshape how care is delivered, accessed and managed.
Below, we’ve highlighted some of the most notable startups and innovators helping put Colorado on the healthtech map.
Top Healthcare Startups in Colorado
- Alto Pharmacy
- DispatchHealth
- CirrusMD
- OrthoFi
- Orderly Health
- Virta Health
- Prime Health
- C3LX Inc.
Healthcare Startups in Colorado to Know
Location: Denver
Founded: 2012
What they do: Prime Health is a nonprofit and innovation ecosystem of more than 1,200 healthtech companies, entrepreneurs and healthcare leaders dedicated to improving healthcare and advancing health equity. It qualifies, tests and supports member companies in developing and integrating new innovations in the healthcare industry. Prime Health also hosts annual innovation summits and challenges, including the annual Prime Health Innovation Challenge in Colorado.
Location: Broomfield
Founded: 2014
What they do: C3LX operates the XIAhealth platform, a remote patient monitoring and care management solution that combines device data, risk factor tracking and behavioral insights to support value-based care practices. The platform integrates with electronic medical records systems to enable care teams to engage and monitor at-risk patients in real time, supporting pre-diabetes prevention and broader chronic disease management across patient populations.
Location: Denver
Founded: 2015
What they do: Orderly Health is a data management platform that automatically cleans, validates and corrects provider directory data for healthcare payers, providers and technology companies. By using machine learning and AI, Orderly Health helps healthcare organizations improve data accuracy and reduce operational costs through automated roster management and provider data updates.
Location: Denver
Founded: 2013
What they do: DispatchHealth is a virtual healthcare enablement company that partners with health systems and risk-bearing providers to deliver hospital-level at-home care programs and complex care in patients' homes. The company’s CESIA technology platform uses real-world patient data and AI to streamline care delivery planning for hospital-at-home, emergency room avoidance and transitional care.
Location: Denver
Founded: 2015
What they do: Alto Pharmacy is a digital pharmacy platform that combines technology with expert pharmacist support to deliver prescriptions directly to customers. It offers same-day delivery, lower prices and on-call support via text or chat, serving customers through both a mobile app and website. Alto’s corporate headquarters is located in San Francisco, but Colorado is a major operational hub for the company, where it has a large centralized care operations facility and a local fulfillment center in Denver.
Location: Denver
Founded: 2012
What they do: CirrusMD provides text-based virtual care that connects patients with physicians in under 60 seconds at any time across all 50 U.S. states. It enables users to chat with doctors about acute and chronic conditions without scheduling delays, plus offers healthcare navigation support to help patients understand insurance coverage and medication information.
Location: Denver
Founded: 2013
What they do: OrthoFi is a platform that helps orthodontists grow their practices through patient acquisition, insurance management and revenue cycle services. It combines customer relationship management software with billing and collections capabilities, enabling practices to accept more patients and streamline operations while also helping patients access affordable orthodontic care through flexible payment options.
Location: Denver
Founded: 2014
What they do: Virta Health offers personalized treatment for patients with type 2 diabetes and obesity through remote medical care, nutrition therapy and health coaching. The company helps patients reduce or discontinue medications through a nutrition-first approach that emphasizes carbohydrate restriction and metabolic health, combining medical supervision, personalized diet guidance, biomarker tracking and virtual coaching.
