Jobs at Eli Lilly and Company

Leads integrated preclinical ADME strategy for radioligand therapeutics discovery. The role integrates pharmacokinetics, metabolism, toxicology, pharmacology, modeling, and medicinal chemistry to guide compound design, translational studies, candidate selection, and go/no-go decisions. Responsibilities include representing ADME on cross-functional teams, establishing screening and decision frameworks, supporting regulatory readiness, improving data and automation practices, participating in governance reviews, and mentoring junior scientists.

Lead ADME strategy for discovery projects by integrating ADME, PK/PD, and translational modeling to guide compound design and candidate selection. Act as ADME single-point-of-accountability on cross-functional teams, define profiling and decision funnels, support dose selection with quantitative modeling, drive assay innovation and AI adoption, maintain regulatory-ready documentation, and mentor junior scientists.

The Senior Principal Scientist will conduct bioanalysis of drug molecules using mass spectrometry, mentor junior scientists, and support drug discovery projects in oncology.

Leads global bioanalytical and biomarker strategy for orexin drug programs from discovery through clinical development. Oversees internal teams, CROs, vendors, assay development and validation, data interpretation, regulatory submissions, budgets, and compliance with global guidelines. Partners with discovery, toxicology, pharmacokinetics, clinical pharmacology, regulatory, and clinical development teams across international regions. Requires deep LC-MS/MS expertise, extensive pharmaceutical or CRO experience, scientific leadership, and global outsourcing management.

Leads early clinical development and clinical pharmacology programs from preclinical planning through Phase 1 and Phase 2 studies. Designs and oversees clinical trials, protocols, biomarker studies, safety monitoring, regulatory submissions, data dissemination, and investigator collaboration. Partners with research, statistics, safety, regulatory, and commercial teams while ensuring GCP and regulatory compliance. Provides scientific leadership, supports product strategy and commercialization, engages external experts, and develops clinical research talent.

Provide strategic patent counseling for key pharmaceutical assets: develop global patent filing and prosecution strategies, assess freedom-to-operate and IP risk, advise senior management, lead projects and task-directed teams, and drive continuous improvement in patent practice.

Own end-to-end security architecture and risk posture for a strategic, AWS-heavy program protecting trade secrets and sensitive intellectual property. Lead cloud and application security reviews, threat modeling, risk assessments, control design, and risk acceptance. Develop secure reference architectures, design patterns, standards, and guidance across cloud platforms, data flows, identity, and integrations. Provide technical leadership, mentorship, and security direction while communicating risks effectively to technical, business, audit, and executive stakeholders.

Leads early-phase clinical development and clinical pharmacology studies from first-in-human planning through execution, analysis, reporting, and regulatory submission. Designs protocols, oversees clinical trials, monitors patient safety, supports biomarker and preclinical strategies, ensures GCP and regulatory compliance, disseminates scientific data, collaborates with cross-functional teams and external experts, and contributes to commercialization and medical strategy. The role also includes developing scientific talent and managing teams.

Leads clinical development programs for diagnostic radiopharmaceutical imaging across oncology, immunology, and cardiovascular disease. Defines study strategies, endpoints, imaging criteria, biomarkers, and patient populations; interprets molecular imaging data and performance metrics; guides image-analysis validation; and collaborates with physicians, scientists, CROs, academics, software developers, and scanner manufacturers. Authors clinical and regulatory documents, evaluates emerging imaging technologies and AI, and communicates findings through presentations and publications.

Provides statistical leadership for pharmaceutical clinical development programs, including trial design, protocol and statistical analysis plan development, data analysis, regulatory submissions, scientific communications, and interpretation of results. Leads innovative statistical methodology, collaborates across data sciences and therapeutic-area teams, responds to regulators, peer-reviews statistical work, and influences clinical and business decisions.

Leads Lilly’s enterprise pandemic preparedness, infectious disease risk management, and public health emergency response strategy. Establishes governance, readiness metrics, response plans, continuity strategies, and crisis leadership structures across research, clinical development, manufacturing, supply chain, and corporate functions. Monitors infectious disease intelligence, advises executives and the Board, coordinates cross-functional emergency responses, develops public health partnerships, and oversees preparedness training, simulations, and after-action programs.

Leads clinical data management for global development programs, including data strategy, electronic trial system implementation, data standards, validation, quality oversight, vendor management, reporting, documentation, and regulatory compliance. Partners with CROs and cross-functional teams to deliver accurate, timely clinical data and support submissions, inspection readiness, and clinical milestones across complex Phase I–III studies.

Leads clinical development programs for diagnostic radiopharmaceutical imaging across oncology, immunology, and cardiovascular disease. Defines study strategies, endpoints, imaging criteria, biomarkers, and patient populations; analyzes PET, SPECT, CT, and MRI data; evaluates imaging performance and advanced image analysis methods; and guides regulatory documentation. Collaborates with physicians, scientists, physicists, CROs, academics, software developers, and scanner manufacturers while communicating findings through publications and presentations.