POSITION SUMMARY:

The primary role of this position is to engineer maintainable and well-tested tools for genomic sequence data analysis while adhering to ArcherDX software engineering methodologies. The bioinformatician will create novel tools, customize existing ArcherDX and third party tools in order to improve and accommodate new and existing applications of ArcherDX products.

The bioinformatician will work closely with molecular biologists to analyze and interpret the results of laboratory experiments and will be able to provide guidance on how to best design their experiments. This individual will elicit requirements from the Molecular Biology team in order to build tools that will facilitate assay optimization and new product development. Assay optimization and new product development will involve determining the best assay parameters by applying and interpreting statistical analysis of the data and by creating rich visualizations of the data. It will also involve novel algorithm creation via rapid prototyping followed by rigorous testing to show the viability of new concepts.

RESPONSIBILITIES:

• Exploratory analysis that facilitates data driven decisions
  • Analysis built to be reproducible and extended for new problems
  • Reports that tell a story about the data and draws conclusions
  • Presentations that are easily digestible by molecular biologists 
• Data analysis and visualization
  • Rich figures and tables that show complex data simply
• Algorithm testing, optimization and development
  • Use of statistical modeling, machine learning and bioinformatics to create highly sensitive and specific algorithms for the detection of genomic aberrations in NGS data
• Design scalable, maintainable and well tested commercial grade software
  • Use and refine agile-like processes in order to produce high quality software
• Follow team policies for producing both ad-hoc analysis and commercial software
  • Show discipline in adhering to team adopted processes 
• Review, understanding, and compliance with ArcherDX HIPAA Security policies and procedures.
• Safeguarding the privacy and security of protected health information and European Union personal data.
• Processing and handling of European Union personal data only as directed by ArcherDX for purposes of personalized molecular pathology.
• Additional duties as assigned

EXPERIENCE:

• 0-6 years of bioinformatics experience
  • Experience, education and skill set will determine title and compensation
• Understand the basics of molecular biology as it pertains to human disease, primarily in cancer
• Proficiency with Python (or any object-oriented language) and standard NGS bioinformatics tools (e.g. GATK, BOWTIE, BWA, etc.)
  • Additional experience with lower level languages like C++ and C are a plus
• Ability to design, create and query relational databases (No-SQL experience a plus)
• Machine learning in NGS applications
• Proficiency with iPython notebook is a plus
• Proficiency in statistics is a plus
• Formal software development experience is plus
• Proficiency in object oriented design principals is a plus
• Understanding of FDA regulations for software development in medical devices is a plus

*The candidate as a whole will be evaluated and strengths in one area may make up for lack of experience in others